TOP2A and nonpapillary renal cell carcinoma: To further explore the potential mechanism of distant metastasis in ccRCC, all of the interactional key genes including the three key lncRNAs (LINC01234, LINC02577, and LINC02609), three key miRNAs (hsa-miR-10b-3p, hsa-miR-23b-3p, and hsa-miR-139-3p), and four hub mRNAs (CCNB2, KIF18B, PLK1, and TOP2A) in the network were extracted to form a core ceRNA network, and visualized by the Sankey diagram, in which all genes were significantly associated with distant metastasis and prognosis in patients with ccRCC (Figure 8H).