The results indicated that the three key miRNAs (hsa-miR-10b-3p, hsa-miR-23b-3p, and hsa-miR-139-3p) were not only significantly negatively related to the expression of four targeting hub mRNAs (CCNB2, KIF18B, PLK1, and TOP2A, Figures 6G–K) and higher pathological stages in patients with ccRCC (Figures 6L–N) but also significantly low-expressed in distant metastasis tissues (Figures 6O–Q). Here, PLK1 is linked to nonpapillary renal cell carcinoma.