To further explore the potential mechanism of distant metastasis in ccRCC, all of the interactional key genes including the three key lncRNAs (LINC01234, LINC02577, and LINC02609), three key miRNAs (hsa-miR-10b-3p, hsa-miR-23b-3p, and hsa-miR-139-3p), and four hub mRNAs (CCNB2, KIF18B, PLK1, and TOP2A) in the network were extracted to form a core ceRNA network, and visualized by the Sankey diagram, in which all genes were significantly associated with distant metastasis and prognosis in patients with ccRCC (Figure 8H). The gene discussed is PLK1; the disease is nonpapillary renal cell carcinoma.