Finally, we took the four hub mRNAs (CCNB2, KIF18B, PLK1, and TOP2A), three key miRNAs (hsa-miR-10b-3p, hsa-miR-23b-3p, and hsa-miR-139-3p) and three key lncRNAs (LINC01234, LINC02577, and LINC02609) screened above together to construct a ceRNA network that could regulate the distant metastasis and prognosis in ccRCC. This evidence concerns the gene TOP2A and nonpapillary renal cell carcinoma.