After conducting a series of rigorous analyses, such as PPI analysis, survival analysis, expression analyses in stage, grade, and distant metastasis to genes in the pink module, a total of six hub mRNAs (BUB1B, CCNB2, KIF18B, PLK1, PTTG1, and TOP2A) that could predict distant metastasis and poor prognosis in patients with ccRCC were successfully identified. This evidence concerns the gene PLK1 and nonpapillary renal cell carcinoma.