CUL4B level in low-grade gliomas (LGGs, grade II) was slightly higher than that of adjacent non-malignant tissues (Figure 1A and Supplementary Figure 1B), whereas CUL4B expression was notably elevated in more aggressive high-grade gliomas (HGGs, grade III and IV GBM), comparing to the paired non-cancerous tissues (Figures 1A, B). The gene discussed is CUL4B; the disease is central nervous system cancer.