Consistently, POU5F1 and PRDM14 master stem cell regulators were identified by GSEA of the ESCAPE stem cell-focused database as top up-stream regulators, while pathways in Cancer (KEGG 2019 Human database) and Axon Guidance (KEGG 2019 Mouse database) were scored as top significantly-enriched pathways. The gene discussed is POU5F1; the disease is cancer.