Previous study had indicated that EGF/EGFR signaling pathway plays an important role in the production of CXCL5 in HCC, and then activates downstream signaling pathways, thus mediating inflammatory microenvironment, as well as cell proliferation, apoptosis, and metastasis, revealing the signaling pathway of CXCL5 in HCC. Here, EGFR is linked to hepatocellular carcinoma.