Checkpoints inhibitors, such as programmed death receptor-1 (PD-1), programmed death receptor ligand-1 (PD-L1), are likely to exert anti-tumor effects in this immunophenotype; the immune-excluded tumor shows that there are a large number of immune cells around the tumor cells, but the immune cells cannot penetrate into the core of the tumor cells and are restricted to the peripheral matrix of the tumor cells. This evidence concerns the gene CD274 and neoplasm.