Promoter methylation analysis of TCGA lung cancer dataset in SMART portal indicates that the Limd1 gene promoter is highly methylated in a region spanning nucleotides 45559963 to 45678725 in both LUAD and LUSC, exemplified by the probe cg15765353 that covers the two nucleotides 45559963-4 (p=4e-7 for LUAD and p=9.1e-11 for LUSC) (Figures 2F, G). This evidence concerns the gene LIMD1 and lung cancer.