LIMD1 and acute myeloid leukemia: For example, LIMD1 interacts with the tumor suppressor Rb to inhibit E2F-mediated gene transcription in the nucleus in AML (2), with VHL, PHD, and RHOBTB3 to repress HIF1α activity by promoting its ubiquitination-mediated degradation in response to cancer hypoxia (5, 13), and with LATS and WW45 to negatively regulate the anti-oncogenic Hippo signaling (14).