MYC and cancer: Yan et al. found that extracellular-vesicle-encapsulated miR-105 secreted by breast cancer cells was capable of inducing a metabolic program in CAFs: (1) enhancing glucose and glutamine metabolism to supply adjacent cancer cells; (2) accelerating elimination of wastes and detoxifying metabolic wastes, with the conversion mediated by activating MYC signaling in CAFs (38); and (3) biasing the nutrient “competition” toward cancer cells.