Lan et al. found that M2 macrophage–derived exosomes (MDEs) displayed a high expression level of miR-21-5p and miR-155-5p, which bound to the Brahma related gene 1(BRG1)-coding sequence after being absorbed by CRC cells and downregulated the expression of BRG1, thus promoting cell migration and invasion in colon cancer (99). This evidence concerns the gene SMARCA4 and colorectal carcinoma.