F2RL3 and cancer: Shen et al. demonstrated that the overexpression of miR-7 in CAFs led to the downregulation of RAS-association domain family 2 (RASSF2), a member of Ras-association domain family of protein, which dramatically decreased the secretion of protease-activated receptor-4 (PAR-4) from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells (59).