SMARCA4 and colonic neoplasm: Lan et al. found that M2 macrophage–derived exosomes (MDEs) displayed a high expression level of miR-21-5p and miR-155-5p, which bound to the Brahma related gene 1(BRG1)-coding sequence after being absorbed by CRC cells and downregulated the expression of BRG1, thus promoting cell migration and invasion in colon cancer (99).