Recently, Eder and colleagues reported that ectopic expression of active nuclear YAP1 (nlsYAP5SA) or conditional deletion of YAP1’s negative regulators LATS1 and LATS2 kinases in neural progenitor cells in ventricular zone also induced tumors which display molecular and ultrastructural characteristics of human ependymoma (104, 105). The gene discussed is YAP1; the disease is ependymoma.