TGFB1 and medulloblastoma: The NeuroD2:SmoA1 medulloblastoma model was also used to show that blocking TGF-β signaling promoted memory T cell development thereby conferring antitumor immunity (124) and in Atoh1-Cre;Ptch1fl/fl mice, tumor astrocyte-derived Shh induced the proliferation of medulloblastoma tumor cells (125).