We then evaluated the prognostic values of CSRNPs in high- and low- mutant burden patients in all enrolled patients with ccRCC, and found that both CSRNP1 and CSRNP3 act as protective factors in both high- and low-mutant burden patients (Figures 5B, E, D, G). Here, CSRNP1 is linked to nonpapillary renal cell carcinoma.