Besides, on the basis of the research conducted by Zou et al., in gallbladder cancer, the positive expression of PDIA3 and CCT2 was significantly associated with clinicopathological features of both squamous carcinoma/adenosquamous carcinoma and adenocarcinoma specimens, consisting of lymph node metastasis and high TNM stage (22). Though there were several valuable outcomes, much more work related to BLCA, ESCA, HNSC, STAD, UCEC, and renal tumors remains to be done, which will inevitably lead to a much more comprehensive understanding of the function of CCT2 in numerous cancers. This evidence concerns the gene PDIA3 and squamous cell carcinoma.