CAD and neoplasm: Besides, based on the study conducted by Lu et al., they discovered that as an essential enzyme in de novo synthesis of purine, phosphoribosylformylglycinamidine synthase (PFAS) interacted with several proteins which played physiological roles in tumor development including CAD, CCT2, PRDX1, and PHGDH, and it was also able to deamidate PHGDH, and induce other posttranslational modification into CAD, CCT2, and PRDX1 (37). When it comes to other subunits of CCT complex, previous studies have reported some valuable points.