CCT5 and breast carcinoma: By depleting or overexpressing the subunit in breast cancer and breast epithelial cells, they found that increasing CCT2 in cells by 1.3–1.8-fold also increased other CCT subunits’ (CCT3, CCT4, and CCT5) levels, while silencing the expression of CCT2 by ~50% was able to cause other CCT subunits to reduce.