Moreover, CAV1 expression levels within the tumor epithelium seem to correlate with OS: with increasing CAV1 scores of the tumor epithelium the OS deteriorated (Figure 2F), an effect that was even more prominent when only the p16-negative tumors (n=27) were investigated (Figure 2G), most likely due to the fact that p16-positive tumors were shown to express less epithelial CAV1 (Figure 2E). Here, CAV1 is linked to neoplasm.