At present, patients with BRAF V600-mutant metastatic melanoma are recommended for combination treatment with BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi), such as dabrafenib+trametinib (D+T), vemurafenib+cobimetinib (V+C), and encorafenib+binimetinib (E+B), because the combination can block the negative feedback loops for the activation of the MAPK pathway and delay the development of drug resistance (5–7). The gene discussed is MAP2K7; the disease is metastatic melanoma.