At present, patients with BRAF V600-mutant metastatic melanoma are recommended for combination treatment with BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi), such as dabrafenib+trametinib (D+T), vemurafenib+cobimetinib (V+C), and encorafenib+binimetinib (E+B), because the combination can block the negative feedback loops for the activation of the MAPK pathway and delay the development of drug resistance (5–7). Here, BRAF is linked to metastatic melanoma.