RUNX2 and colorectal carcinoma: Ji et al. (2019) showed that PTBP2 could elevate translational levels of RUNX2, which plays a vital role in CRC metastasis. NOVA1 expression controls the proliferation and invasive properties of CRC cells by enhancing IL-6/JAK2/STAT3 signal transduction, and in turn, up-regulating matrix metalloproteinases (MMPs) 2, 7 and 9 (Hong et al., 2019). CRC associated with inflammation by activation initiated TLR3 and TLR7 (He et al., 2017). EZH2 expression and activity are associated with colorectal carcinogenesis and are most often expressed in highly intraepithelial lesions (Bremer et al., 2021).