Prior studies suggested that the role of MMP11 is unique, and includes tissue remodeling, progesterone sensitivity, and the promotion of tumor development (Itoh et al., 2012), and is correlated with poor outcomes in different estrogen-dependent cancers (Nasu et al., 2001; Callegari, Ferguson-Gottschall & Gibori, 2005). Here, MMP11 is linked to neoplasm.