We found that the tumor genes, including TEX41, POLQ, and FLT1 were expressed through up-regulation, and tumor suppression genes such as PLCD1 and OSR2 were expressed through down-regulation in the ectopic endometrial cell group, suggesting ectopic endometrial cells may have more risk of malignant transformation than eutopic endometrial cells. The gene discussed is OSR2; the disease is neoplasm.