Despite several reports showing that minocycline improved aspects of each individual complication [8,10–13,34–36], the current study represents the first time the simultaneous effects of minocycline on DPN, DR, and DKD were compared in a STZ-induced T1D model and a leptin signaling-deficient T2D model on a BKS background. The gene discussed is LEP; the disease is type 1 diabetes mellitus.