APC and gastric cancer: As a disease is involved with a myriad of factors, the gastric cancer is closely associated with its risk factors namely genetic factors (mutation in P53, MCC, and APC), epigenetic factors (dysregulation of gene expression in GC), and environmental factors (Helicobacter pylori infection, gastric ulcer, gastroesophageal reflux disease, alcohol, smoking, obesity, radiation, Epstein Barr virus infection, blood group, socioeconomic status, and gender (the male twice in number) (1-4).