We compared the DBP staining pattern with TC staging; we found a significant inverse correlation to advance staging in FATC i.e., low (+) to no (0) DBP in advance staging), whereas moderate (++) to strong (+++) DBP accumulation was observed in early staging of thyroid cancer in EATC with stronger staining in tumor vessels, stromal cells, and thyroid cancer tissues. This evidence concerns the gene DBP and thyroid gland carcinoma.