In contrast to Prx1 but similar to Prx4, Grx2 in healthy skin biopsies was found to be distinctively expressed in the basal layer with decreasing concentration in the stratum spinosum, while in PV patients, it was moderately expressed only in the polymorphonuclear cell infiltrate and the nuclei of epithelial cells. Here, GLRX2 is linked to acquired polycythemia vera.