Since Trx1 in general is considered beneficial for wound healing [39], it would here be intriguing to see if CAP-induced local loss of Trx1 indeed leads to a Trx1 secretion in this model and in vivo, therefore increasing systemically available Trx1 to counteract local oxidative dysregulation found in epidermal erosions in pemphigus. This evidence concerns the gene TXN and pemphigus.