Nobiletin combined with paclitaxel, carboplatin, and other chemotherapeutic drugs can significantly inhibit the growth of subcutaneous A549 tumor xenotransplants in mice and enhance the sensitivity of A549 cells to chemotherapeutic drugs by regulating various signaling pathways such as the Akt/GSK3β/MYCN pathway [74, 75]. The gene discussed is AKT1; the disease is neoplasm.