TGFB1 and Abnormal renal physiology: Additionally, both SNVs were significantly associated with pre-transplant renal dysfunction, with this morbidity occurring in 30% of participants with the TGFB1 rs4803455 C/C genotype vs. 16% of variant A carriers (p = 0.018), and 12% of participants with the PLCB1 rs170549 G/G genotype vs. 30% of variant A carriers (p = 0.002).