Given published evidence on transport of ThDP by cellular membrane transporters SLC19A1 (Zhao et al., 2001; Zhao and Goldman, 2013) and SLC44A4 (Nabokina et al., 2014), this experimental design may overcome complex regulation of ThDP synthesis in cancer cells (Jonus et al., 2018), being more straightforward to extend the interval of intracellular ThDP content. Here, SLC44A4 is linked to cancer.