By profiling the genetic variant MTHFR C677T among IS with different origins, Rutten-Jacobs et al. (2016) reported that MTHFR C677T was associated with lacune and higher white hyperintensity, but not LAS or CES, which partly explained the uncertainty about the efficacy of lowering Hcy treatment for stroke patients. This evidence concerns the gene MTHFR and stroke disorder.