ALDH7A1 and pyridoxine-dependent epilepsy: Pyridoxine-dependent epilepsy (PDE, OMIM: 266100) is a clinical disorder that typically presents in infancy or early childhood, caused by a deficiency of aldehyde dehydrogenase 7 family member A1 (ALDH7A1) which was first identified in 2006 (Hunt et al., 1954; Mills et al., 2006).