RRM2B amplifications also significantly correlated with an increase in RRM2B mRNA expression in OC and BC, and with an increased trend in HNSCC (OC: Pearson correlation = 0.64, Log rank p-value = 0.05; BC: Pearson correlation = 0.53, Log rank p-value = 0.04; HNSCC: Pearson correlation = 0.32, Log rank p-value = 0.08) (Supplementary Figure 2). Here, RRM2B is linked to breast cancer.