PFKFB3 and neoplasm: LncRNAs CamK-A, BRCA4, and AGPG wires up NF-kB (Engreitz et al., 2016), Hippo and Hedgehog (Zheng et al., 2017), and PFKFB3 glycolytic enzyme complexes (Liu et al., 2020), respectively, to remodel glucose metabolism and tumor microenvironment, promoting tumor development.