CDKN1A and breast carcinoma: PVT1 has been identified as a prognostic biomarker and played a critical role in the development of pancreatic ductal adenocarcinoma via triggering cytoprotective autophagy (Huang et al., 2018), and it affected EMT and cell proliferation and migration via modulating CDKN1A expression in breast cancer (Wang et al., 2018).