IL6 and cancer: Ex vivo and in vitro experiments revealed that IL-6 could enhance the adsorption between colon cancer cells and CTLs by upregulating the expression of cell adhesion molecule ICAM1 and polarize CTLs into cancer cells through STAT3, STAT5, ERK, and Rho-ROCK signaling pathways, both of which facilitated the formation of cell-in-cell structure.