GZMB and neoplasm: Subsequently, suppresser cells, including tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), Tregs, Bregs, MDSCs, and pDCs, etc. are assembled in context-dependent manners and intervene with the anti-tumor immunity shaped by effector cells, where granzyme B possesses dual opposing roles depending on the cell source and relative abundance of those cells in TME (88, 93).