Tumor cells, TAMs, tumor-associated neutrophils (TANs), Tregs, and MDSCs generally secrete TGF-β while express surface PD-L1 that binds with PD-1 on T cells, which all together promote the expression of FoxP3, thus differentiating T cells into GrBhigh iTregs (129). The gene discussed is CD274; the disease is neoplasm.