In patients with cirrhosis, sCD163 and sMR significantly correlate with severity (e.g. MELD and Child-Pugh scores) as well as the degree of portal hypertension (164–167); high plasma concentrations of sCD163 associate with variceal bleeding in cirrhotic patients and predict mortality in alcoholic hepatitis (165, 168). This evidence concerns the gene CD163 and Cirrhosis.