While new and exciting functions of GSDMD are mainly characterized in myeloid cells, the role of GSDME in host defense remains poorly characterized and is mainly characterized in tumor cells, where cleavage of GSDME by apoptotic caspase-3 and -7 or granzyme B switches tumor cell apoptosis to pyroptosis (7, 22, 24). The gene discussed is GSDMD; the disease is neoplasm.