In our analysis, the association with DPN remained unchanged for sTNFRI, sTNFRII, sIL2Rα, IGFBP6 and CRP, after adjusting for HbA1c levels in study subjects, suggesting that factors other than hyperglycemia are also involved in pathogenesis of DPN (36). The gene discussed is IGFBP6; the disease is Hyperglycemia.