The subject’s duration of T1D disease burden was significantly correlated with IGFBP1 (r=0.16, p=0.0003), IGFBP2 (r=0.26, p=2.2x10-9), MMP2 (r=0.22, p=1x10-6), and sTNFR2 (r=0.18, p=7.2x10-5). This evidence concerns the gene IGFBP1 and type 1 diabetes mellitus.