For example, an allelic variant of MICA-129 was described to be associated with systemic lupus erythematosus (135), MICA*002 allele can have an effect in reducing the risk of primary sclerosing cholangitis (136), MICB*004 allele is associated with rheumatoid arthritis (137) and expression of ULBP3 is upregulated in patients with alopecia areata (138). This evidence concerns the gene ULBP3 and rheumatoid arthritis.