Using the compound library together with proteomics and metabolomics, we identified factors/pathways that are modulated by EGFR-HIF-1α pathways in Salmonella infection, and therefore hypothesize that blocking these factors/pathway during Salmonella infection may lead to provide new targets of HDT for eliminating intracellular pathogens. The gene discussed is EGFR; the disease is Salmonella Infections.