MICA and neoplasm: When we analyzed the clinical characteristics of GC patients in relation to MICA polymorphisms, we observed that MICA-129, MICA-181 and MICA-sequence alleles were not related to tumor size, TNM stating or tumor differentiation grade in this type of cancer, whereas, tumors from MICA*A9/A6 heterozygote patients, who thus possess combinations of MICA*002 and MICA*009/049 or MICA*004, showed poorly differentiated tumors.