Chronic inflammation of COPD is mediated by innate immunity (neutrophils) and adaptive immunity (CD4+ T cells), especially in small airways, the degree of inflammation correlates with the severity of the disease classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (3–6).However, recent evidences illustrate that innate immune-like cells are equivalently important involved in the pathogenesis of COPD. The gene discussed is CD4; the disease is chronic obstructive pulmonary disease.