CD8A and neoplasm: have reported that the binding of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) to the transcripts encoding lysosomal proteases modified by m6A methylation improved the translational efficiency of lysosomal cathepsins in DCs, whereas the suppression of cathepsins in DCs significantly strengthened its ability to cross-present tumor antigens, which in turn enhanced the tumor infiltrating CD8+ T cell antitumor response (91).