In breast cancer, the MLL4-mediated H3K4me2 and the CBP/p300-c-Myc complex-mediated H3ac contribute to self-renewal of CSCs by regulating the expression of epithelial–mesenchymal transition (EMT) regulators, such as SNAIL, ZEB1, and ZEB2, in the absence of KDM6A (124). Here, KDM6A is linked to breast carcinoma.