KDM6A and breast cancer: In breast cancer, the MLL4-mediated H3K4me2 and the CBP/p300-c-Myc complex-mediated H3ac contribute to self-renewal of CSCs by regulating the expression of epithelial–mesenchymal transition (EMT) regulators, such as SNAIL, ZEB1, and ZEB2, in the absence of KDM6A (124).