KDM6A and neoplasm: KDM6A (also known as UTX), a component of the MLL complex, recruits LSD1, HDAC1, and DNMTs to form a complex that inhibits H3K4me2 and H3ac, and enhances DNA methylation at the promoter regions of SNAIL, ZEB1, and ZEB2, thereby resulting in abolished CSC self-renewal, tumor proliferation, and migration (124).