HMGB1 and systemic lupus erythematosus: Ingenuity Pathway Analysis further identified an enrichment of the STAT3 pathway (41), glutathione-mediated detoxification (42), leukotriene biosynthesis (43), IL-8 signaling (44), HMGB1 signaling (45), NRF2-mediated oxidative stress response (46), systemic lupus erythematosus in B cell signaling pathway (47), and T cell exhaustion signaling pathway (48) in the Nox2 gene signature and are in association with MS or EAE (Table 1 and Supplementary Table 4).