Previous research pointed out that the activation of STAT3 in myeloid cells is essential for leukocyte infiltration, neuroinflammation, and demyelination in EAE mice (41), while phosphorylated STAT3 was also observed in microglia, macrophages, and astrocytes in the white matter adjacent to active MS lesions (68). The gene discussed is STAT3; the disease is myeloid sarcoma.