Gene ontology analysis performed on the KEGG pathways (Supplementary Table 3) revealed DEG enrichment in six pathways that are associated with virus infection (human papillomavirus infection, herpes simplex virus 1 infection, and human T-cell leukemia virus 1 infection), which are known to be associated with EAE-related signaling pathways, such as the MAPK and PI3K-Akt signaling pathways as well as cytokine-cytokine receptor interaction (Figure 7D). This evidence concerns the gene AKT1 and viral infectious disease.