Using their hu-spl-PBMC-NSG model, they discovered that their duoCAR construct, by which m136.4 and mD1.22 were expressed as individual CARs on the same cell, was able to suppress HIV-1 infection for up to 30 days while mitigating CD4+ T cell depletion, compared to their monoCAR or untransduced counterparts (58). The gene discussed is CD4; the disease is HIV-1 infection.