For example, NKA α1 subunit (ATP1A1) is upregulated in non-small cell lung cancer (NSCLC) (45), esophageal squamous cell carcinoma (ESCC) (46), renal cell carcinoma (47), glioma (48), but downregulated in prostate cancer (49). Here, ATP1A1 is linked to esophageal squamous cell carcinoma.