For example, NKA α1 subunit (ATP1A1) is upregulated in non-small cell lung cancer (NSCLC) (45), esophageal squamous cell carcinoma (ESCC) (46), renal cell carcinoma (47), glioma (48), but downregulated in prostate cancer (49). The gene discussed is ATP1A1; the disease is renal cell carcinoma.