To investigate the role of ATP1B3 in HCC, we transfected ATP1B3 siRNA (Hhu7-siATP1B3 and HCCLM3-siATP1B3) into Hhu7 and HCCLM3 cells to knockdown ATP1B3 expression (Figures 10A, B), and then analyzed the effects of silenced ATP1B3 on HCC cells proliferation, migration, invasion and cycle, apoptosis. The gene discussed is ATP1B3; the disease is hepatocellular carcinoma.