A study based on the interaction of hepatoma cells with HBV suggested that the downregulation of HBV in hepatoma cells with siRNA changed the expression profile of some of the IFN-stimulated genes (IFI6, MDA5, IFI27, STAT1, IFIT1, ISGF3G, IFITM1, OAS1, and G1P2). This evidence concerns the gene ISG15 and hepatocellular carcinoma.