In SLE, lymphocytes-PLTs aggregates had an up-regulation of CD86, B cell activation factor receptor and IL-10 production and correlated positively with plasmatic levels of IgG, IgA, IL-10, sCD40L and renal manifestation, and correlated negatively with IgM levels (100). The gene discussed is CD40LG; the disease is systemic lupus erythematosus.