Nevertheless, in patients with severe COVID-19, a dysfunctional immune response occurs, triggering a cytokine storm, in which an increase of IL-2, IL-6, IL-7, IL-10, Granulocyte Colony-Stimulating Factor (G-CSF), IP-10, MCP-1, Macrophage Inflammatory Protein 1α (MIP-1α) and Tumor Necrosis Factor-alpha (TNF-α) in plasma blood levels are observed (27, 28). This evidence concerns the gene TNF and COVID-19.