CD40 and Anxiety: Frequencies of CD40 positive (+) and CD83+ cells were significantly increased in mice under anxiety stress than in control mice (41.80 ± 7.19% vs. 25.94 ± 4.16%, p = 0.008; 27.78 ± 5.45% vs. 11.20 ± 3.88%, p = 0.008, respectively) (Figures 4A, B).