PPARA and metabolic dysfunction-associated steatotic liver disease: In addition to histone acetylation, CUR was shown to repress DNA hypermethylation at CpG sites within the promoter region of peroxisome proliferator-activated receptor-alpha (PPARα) by inhibiting DNMTs in a non-alcoholic fatty liver disease, which results in upregulated PPARα expression and reduced liver cell death (180, 181)., PPARα, a transcription factor that predominates in the liver, regulates the expression of genes involved in inflammation and several metabolic processes (326–330).