It downregulates miR-155 in RAW264.7 (149).RES downregulated miR-21 in human glioblastoma and in different in vitro models (150, 151).RES suppresses miR-146a in RAW 264.7 macrophages (151).RES increased DNMT 3a and 3b expression in the retinal epithelial (ARPE-19) cell line (152).RES deacetylates the promoter region of MMP9 endoproteinase.RES targets HDAC complexes (104–106). The gene discussed is HDAC9; the disease is glioblastoma.