NFE2L2 and experimental autoimmune encephalomyelitis: For example, Li et al. showed that SFN activated the Nrf2 pathway through inhibiting Nrf2 ubiquitination, and concomitantly reduced NF-κB and AP-1 expression, thus restoring endogenous antioxidant levels and reducing inflammatory damage in an experimental autoimmune encephalomyelitis mice model (274–279).