Reduction in LPS-induced inflammation process.Relative inhibition of the levels of inflammatory markers, namely CRP, ox-LDL, CCL-2, CD40, and MMP-2, as well as the proinflammatory cytokines, IL-1β, IL-6, IL-12, and TNF-α in gingivalis-induced atherosclerosis (259).It suppresses the proliferation of inflammation-induced colon cancer cells (260).It increases Nrf2 expression and its downstream targets, and inhibits TPA-induced JB6 cells transformation (261). This evidence concerns the gene CD40 and colonic neoplasm.