Patients with sepsis were grouped, according to their 7-day prognosis (survival/death), and we divided them based on basic conditions including PD-1 expression, expression of six cytokines (IFN-γ, IL-1β, IL-2, IL-6, TNF-α, and IL-10), SOFA scores, APACHE II scores, procalcitonin (PCT) levels, and lactic acid (Lac) levels for comparative analysis. The gene discussed is IL1B; the disease is Sepsis.