CPSF6 and infection: • Participates in the nuclear import step (Christ et al., 2008; Logue et al., 2011).• Involved in post-nuclear entry steps (Valle-Casuso et al., 2012; Shah et al., 2013).• Favors infection by participating in the nuclear localization of CPSF6 (De Iaco et al., 2013; Fricke et al., 2013).