Another role of CypA during infection is to avoid the recognition by the tripartite motif (TRIM) containing protein TRIM5 of the capsid core either by inducing a conformational change through its isomerase activity or by steric hindrance (Kim et al., 2019; Ni et al., 2020; Selyutina et al., 2020a; Yu et al., 2020). Here, PPIA is linked to infection.