Stover et al. screened 64 orbital connective tissue-derived T cell clones expanded from two GO patients and reported an obvious predominance of the CD4+ T cell population (CD4/CD8 ratio 8.2) that contrasted with six PBMC samples (CD4/CD8 ratio 2.1) (39). This evidence concerns the gene CD4 and geroderma osteodysplastica.