These cells express CD45, CD34, CXCR4, collagen I, thyroglobulin, TSHR, and IGF-1R, and were far more frequent in the circulation of GD and GO patients than in control subjects and were highly detected in GO orbital connective tissues, but were absent in control orbits (28, 29, 107). This evidence concerns the gene CD34 and geroderma osteodysplastica.