CXCL10 was higher in GD and GO patients than controls; CXCL10 was significantly higher in active GO patients than inactive GO patients; IFN-γ and TNF-α synergistically induced CXCL10 production in GO thyrocytes, OFs, and preadipocytes, which was suppressed by PPAR-γ agonist. Here, IFNG is linked to geroderma osteodysplastica.