Conversely, we found that classic CD3+CD8-CXCR3-CCR6+ Th17 and non-classic CD3+CD8-CXCR3+CCR6+ Th17.1 cells were elevated among PBMCs from active very severe GO patients compared with both active moderate-to-severe GO and GD patients. This evidence concerns the gene CD8A and geroderma osteodysplastica.