GCG and obesity due to melanocortin 4 receptor deficiency: Excess weight gain (e.g., obesity/overweight) has been associated with impairments in glucose-induced GLP-1 secretion (16–19) and alterations to dorsal striatal response to food cues (20–23), but no study that we are aware of has examined how an interactions between obesity and dietary added sugars are related to postprandial GLP-1 secretion or dorsal striatal food cue reactivity, despite the established potential comorbidity between these two factors (24, 25).