GLP1R and obesity due to melanocortin 4 receptor deficiency: These findings could suggest that GLP-1 analogues, such as liraglutide and exendin-4, may be especially successful weight loss therapies in individuals more likely to exhibit decreases in GLP-1 secretion (e.g., people with obesity and those who habitually consume high levels of dietary added sugar), but this prediction requires further investigation with randomized controlled studies.