(57) have reported that EA at ST36, SP6, CV12 and Tianshu (ST25) may decrease methylation of Tsc1 and suppress the activity of mTORC1, reduce the expression of NPY and AgRP, and promote the expression of POMC, thereby regulating appetite and alleviating obesity. The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.