After adjusting for potential confounders including age, years since menopause, LH, E2, BMI, dyslipidaemia, diabetes, hypertension, smoking, and drinking, the ORs of declined eGFR and CKD were two-fold (OR=2.187, 95% CI: 1.635–2.924) and 10-fold (OR=10.088, 95% CI: 2.279–44.650) higher, respectively, in the highest FSH quartile compared to the lowest (p<0.05), (Table 4). The gene discussed is PLOD1; the disease is inherited lipid metabolism disorder.