Human organs that can cause insulin resistance (IR) by fat deposition mainly include the heart, liver, skeletal muscles and fat (1) Skeletal muscle fat, which includes subcutaneous adipose tissue (SAT), subfascial adipose tissue (SFAT), intermuscular adipose tissue (IMAT), and intramyocellular lipids (IMCL) (2), is one of the major target tissues of insulin and is important for glucose and lipid uptake and utilization in the human body. Here, INS is linked to Insulin resistance.