APOE and Alzheimer disease: Conversely, in ∼35-year-old humans, a positron emission tomography study with [1-11C]-DHA reported that the mean global gray matter incorporation of DHA in the brain of APOE4 carriers was 16% higher than that in non-carriers (Yassine et al., 2017), and this difference was particularly pronounced in the entorhinal region, an area affected early in AD pathogenesis, whereas the rate in the hippocampus was independent of the APOE genotype.